Periostin mediates cardiac dysfunction through activating right ventricular fibroblasts
نویسندگان
چکیده
منابع مشابه
Right ventricular dysfunction predicts clinical outcomes following cardiac resynchronization
Introduction Cardiac resynchronization therapy (CRT) is an established treatment for patients with advanced heart failure (HF). However, a significant proportion of patients do not gain benefit from CRT, the reasons for which are unclear. Despite an established predictive role in HF, the significance of right ventricular (RV) dysfunction in gauging clinical benefit from CRT has not been elucida...
متن کاملAcquired right ventricular dysfunction.
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متن کاملOrigin of cardiac fibroblasts and the role of periostin.
Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles. Significantly, cardiac fibroblasts have also been shown to play an important role in cardiomyocyte growth and expansion of the ventricular chamber...
متن کاملRight ventricular dysfunction persists following brief right ventricular pressure overload.
OBJECTIVE Acute pulmonary hypertension may cause right ventricular (RV) contractile failure. While it has been assumed that restoration of normal loading conditions after acute pulmonary hypertension is sufficient for complete recovery of RV function, this has not been rigorously examined. The purpose of this study was to test the hypothesis that acute RV pressure overload produces RV contracti...
متن کاملMetastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
Metastasis-associated protein, S100A4 is suggested as a marker for fibrosis in several organs. It also modulates DNA binding of p53 and affects its function. However, the functional role of S100A4 in the myocardium has remained unclear. Therefore, we investigated the role of S100A4 and its relationship with p53 in cardiac fibrosis. In Dahl-rat hypertensive heart disease model, S100A4 was upregu...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2019
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.92.0_2-yia-06